Wednesday, October 31, 2012

Indigenous vs. multinationals in Mexico wind power

MEXICO CITY (AP) ? Mexico is putting up wind power turbines at a breakneck pace and the expansion is pitting energy companies against the Indians who live in one of the windiest spots in the world.

The country is posting one of the world's highest growth rates in wind energy, and almost all of it is concentrated in the narrow waist of Mexico known as the Isthmus of Tehuantepec, where winds from the Pacific meet winds from the Gulf of Mexico, spawning places so wind-blown that one town's formal name is simply "Windy."

The largely indigenous residents of the Isthmus complain that the wind farms take control of their land, affect fish and livestock with their vibrations, chop up birds and pit residents against each other for the damage or royalty payments. They also claim they see few of the profits from such projects.

President Felipe Calderon has made the inauguration of wind parks one of the main focuses of his administration's ambitious pledge to cut Mexico's carbon emissions by 30 percent by 2020, and on Tuesday ? as he has done before ? he stopped by the state of Oaxaca to inaugurate a new clutch of wind turbines, praising the extra income they provide for some farmers.

"Yes, you can fight poverty and protect the environment at the same time. This is a clear example," Calderon said at the opening ceremony.

But as in the past, he did so under tight security, as local protesters threatened to mar the inauguration. The president's office normally publishes a detailed schedule of his planned activities, but didn't do so with Tuesday's inauguration, keeping it under wraps until the event took place.

So far in 2012, Mexico has posted a startling 119 percent increase in installed wind-power capacity, more than doubling the 519 megawatts it had last year, the highest annual growth rate listed in the magazine Wind Power Monthly's "Windicator" index. Mexico had only 6 megawatts when Calderon took office in 2006.

While Mexico, with a total of around 1.3 gigawatts of wind power, is still a tiny part of the world's estimated 244 gigawatt capacity, it offers an insight into what happens when the industry focuses overwhelmingly on large farms dominated by large companies that are concentrated in a small, desirable area.

It has been mainly Spanish firms like Iberdrola, Union Fenosa and Gamesa, and U.S. firms like Sempra Energy, that have built the huge wind towers that now crowd the Isthmus of Tehuantepec, leaving the local population feeling invaded. Only 4 of Mexico's 17 wind farms are located outside the isthmus.

It raises the question of whether bigger is always better.

"We are asking these multinationals to please get out of these places," said Irma Ordonez, an activist from the Zapotec Indian town of Ixtepec, Oaxaca. "They want to steal our land, and not pay us what they should."

"When they come in they promise and promise things, that they're going to give us jobs, to our farmers and our towns, but they don't give us anything," said Ordonez, who traveled to Mexico City in October to protest outside the offices of a Mitsubishi Corp.

Industry sources say the distrust is unmerited, given the potential benefits to the poverty-stricken farming and fishing towns on the isthmus.

The latest battle focuses on a huge, 396-megawatt off-shore wind farm planned for a narrow spit of land in a lagoon near the village of San Dionisio del Mar, Oaxaca.

A source close to the project, who was not authorized to speak on the record, said the project had been approved by village assemblies, would have little impact on fishing activities in the lagoon and would contribute an amount equal to about half the township's annual budget in coming years in compensation and royalties.

But opponents and supporters engaged in a tense standoff outside the town in October, when a group of men blocked roads to prevent a planned demonstration against the wind farm.

Saul Celaya, a Huave Indian farmer and San Dionisio resident, said the lagoon project would damage mangrove swamps where fish, shrimp and other sea life breeds, and scare off the fish that locals depend on.

"Just when they were doing soil studies, there was a mass die-off of fish," Celaya said, adding that projects opponents "are being intimidated, they're afraid to leave their houses, they're threatened."

The industry source denied the company was intimidating anyone, but acknowledged the project had suffered some delays due to disputes within the community.

Others say it didn't have to be this way, big corporations pitting villagers against villagers. There are proposals to have local towns start their own wind farms, so that they could decide where they would be situated and where profits should go.

Rodrigo Penalosa, an activist who supports the town of Ixtepec's proposed 100-megwatt community wind farm, noted that "the community has already approved it. The problem is that the (government) Federal Electricity Commission won't allow the community project to get access to the network.... but it does allow the multinationals access."

Sergio Oceransky, whose Yansa Group is trying to help kick-start the community wind project, said the commission is asking for financial guarantees of millions of dollars "that no community in Mexico could meet."

"These are requirements that are basically designed to ensure that only projects presented by multinationals can compete," said Oceransky, who claims that such guarantees are not required by federal law.

The commission did not respond to repeated requests for comment.

With a limited transmission capacity for the projects, and the last lots of line capacity being auctioned off, the situation is becoming critical; what could be a sterling example of alternative energy production is threatening to become a permanent political dispute in southern Mexico.

"This is the last chance," Oceransky says.

Source: http://news.yahoo.com/indigenous-vs-multinationals-mexico-wind-power-050413972.html

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Monday, October 29, 2012

Yeast model offers clues to possible drug targets for Lou Gehrig's disease, study shows

ScienceDaily (Oct. 28, 2012) ? Amyotrophic lateral sclerosis, also called Lou Gehrig's disease, is a devastatingly cruel neurodegenerative disorder that robs sufferers of the ability to move, speak and, finally, breathe. Now researchers at the Stanford University School of Medicine and San Francisco's Gladstone Institutes have used baker's yeast -- a tiny, one-celled organism -- to identify a chink in the armor of the currently incurable disease that may eventually lead to new therapies for human patients.

"Even though yeast and humans are separated by a billion years of evolution, we were able to use the power of yeast genetics to identify an unexpected potential drug target for ALS," said Aaron Gitler, PhD, an associate professor of genetics at Stanford. "Many neurodegenerative disorders such as ALS, Parkinson's and Alzheimer's exhibit protein clumping or misfolding within the neurons that is thought to either cause or contribute to the conditions. We are trying to figure out why these proteins aggregate in neurons in the brain and spinal cord, and what happens when they do."

In 2008, Gitler received a New Innovator award from the National Institutes of Health to use yeast as a model for understanding human neurodegenerative diseases and as a way to identify new targets for drug development.

Gitler is the co-senior author of the research, published online Oct. 28 in Nature Genetics. Robert Farese, Jr., MD, a senior investigator at the Gladstone Institutes, is the other co-senior author. Stanford graduate student Maria Armakola shares co-first authorship with Matthew Higgins, PhD, a postdoctoral scholar at Gladstone.

Most cases of ALS have no clear-cut cause. However, it has recently been shown that an RNA-binding protein called TDP-43 accumulates in clumps in the cytoplasm of spinal cord neurons in many people with the condition, and mutations in this protein have been found in some people with the ALS. Researchers like Gitler and Farese have been able to mimic the disease in yeast by expressing TDP-43 at higher-than-normal levels, which causes the protein to form lethal clumps in the cells' cytoplasm.

"In humans, the progression of the disease can take years before symptoms arise," said Gitler. "But in yeast, we see protein clumping in the cytoplasm within two days and the cells rapidly begin to die." With their model system in place, Gitler and Farese set out to see whether it was possible to protect yeast cells from this effect by tinkering with the function of other proteins in the cell.

In this study, the researchers discovered that blocking the production of a protein called Dbr1 in a yeast model stops the TDP-43 clumping and allows the cells to live normally. The researchers confirmed the results in human nerve cells grown in the laboratory and in rat neurons overexpressing TDP-43.

"In this study we made no assumptions as to how TDP-43 injures cells," said Farese, "but instead screened the whole yeast genome to find genes that might prevent the toxicity. Independently, both our lab and the Gitler lab found that loss of Dbr1, an enzyme involved in RNA processing, could do this."

Dbr1 serves as part of the cellular clean-up crew that mops up the bits of unwanted RNA generated as part of the protein production line. In our DNA, most genes consist of coding regions, called exons, broken up into several segments by non-coding regions, called introns. Cells can make many different, related proteins from the same stretch of DNA by mixing and matching different exons in a process called splicing.

When the DNA is first copied, or transcribed, into RNA, the introns as well as the exons are included. But the cell quickly splices out the introns, which are released into the cytoplasm as little loops, or lariats. Dbr1, in turn, clips the loops to open them and make them accessible to the cell's disposal system.

Blocking the production of Dbr1 causes the RNA lariats to build up in the cytoplasm. The researchers showed -- by creating lariats with a binding site for a fluorescent tracking protein -- that the mutant TDP-43 binds to these excess lariats rather than clumping. The effect is like using a paper towel to mop up a spill on your computer keyboard: binding to the lariats appears to keep TDP-43 from causing havoc elsewhere.

"Normally, TDP-43 is found in the nucleus," said first author Armakola. "But in the diseased cells, it aggregates in the cytoplasm and forms clumps. We developed a novel way to track where these lariats go in living cells, and we saw that when Dbr1 is missing, the lariats act as a sink to sequester TDP-43."

The researchers note that it's still not entirely clear whether the cells die because the mutant TDP-43 is drawing essential RNA transcripts or regulatory molecules away from the nucleus and into the cytoplasm, or because it's not performing its normal RNA-binding function in the nucleus. Both could contribute to the progression of the disease.

The results in the yeast, rodent and human cells, however, suggest that therapeutic approaches aimed at blocking Dbr1 function, or even creating artificial lariat-like formations to draw away the mutant molecule, should be explored.

"Next, we'd like to explore blocking Dbr1 function in animals such as flies, worms and rodents," said Armakola. "We're also interested in identifying small molecule inhibitors of Dbr1."

Other Stanford co-authors include graduate student Matthew Figley. The research was supported by the NIH, the Ellison Medical Foundation, the Packard Center for ALS Research at Johns Hopkins, the Consortium for Frontotemporal Research, the ALS Association, the Taube-Koret Center, the Hellman Family Foundation, the Pew Charitable Trusts, the Rita Allen Foundation, the Searle Scholars Program, the Keck Foundation and the National Center for Research Resources.

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Story Source:

The above story is reprinted from materials provided by Stanford University Medical Center. The original article was written by Krista Conger.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. Maria Armakola, Matthew J Higgins, Matthew D Figley, Sami J Barmada, Emily A Scarborough, Zamia Diaz, Xiaodong Fang, James Shorter, Nevan J Krogan, Steven Finkbeiner, Robert V Farese Jr & Aaron D Gitler. Inhibition of RNA lariat debranching enzyme suppresses TDP-43 toxicity in ALS disease models. Nature Genetics, 28 October 2012 DOI: 10.1038/ng.2434

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/~3/pGA2xXSb4KE/121028142318.htm

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Saturday, October 27, 2012

Pandora Stock Is Cratering On Apple News ... - Business Insider

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Source: http://www.businessinsider.com/pandora-stock-is-cratering-on-apple-news--down-14-so-far-2012-10

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Florida and Ohio, show us your election!

(Tim Jacobs, Dave Kreisman, Joshua Yospyn and Cain and Todd Benson)(Tim Jacobs, Dave Kreisman, Joshua Yospyn and Cain and Todd Benson)

Florida and Ohio residents, it's no mystery that the 2012 presidential candidates see your states' electoral votes as key to winning the election. So, you're getting a lot of attention from President Barack Obama, Mitt Romney and their running mates that the rest of us don't see. We want to know what it's like, and here's your chance to show us! Share your stories and photos with Yahoo! News and we might feature them in a series we're doing about 2012 swing states.

Here's what we're looking for:

1. Share your firsthand observations, stories and anecdotes of what it's like to be in a battleground state. Write between 200 and 400 words, and include colorful details that paint a picture of what it's really like in your state.

Some possible topics to touch on:

-How many political commercials do you see per day? Which ones stick in your mind, and why?

-Are you going to candidate rallies?

-How many of your neighbors have Obama-Biden or Romney-Ryan yard signs?

-What's the best political bumper sticker you've seen?

-Do you know which candidate you're voting for? What about your friends and family? Is there political tension in the air due to differing opinions?

-If you haven't decided on whom to vote for, tell us what could change your mind.

2. We're also publishing readers' photos from the campaign trail, so snap away and share those too! If you're at a campaign event or you've spotted interesting political paraphernalia (think yard signs, bumper stickers, street art and more), snap a picture and send it to us.

You can submit your material several ways: Email us at swingstatestories@yahoo.com (please include your full name and city of residence); join the Yahoo! Contributor Network; tweet your photos to @YahooTicket using the hashtag #SwingStateStories; or join our Election 2012 Flickr group. Please send your content by Thursday, Nov. 1.

Thank you! We look forward to hearing about what the election looks like in your community.

Source: http://news.yahoo.com/blogs/ticket/florida-ohio-show-us-election-141844282--election.html

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AP-GfK poll: Romney erases Obama lead among women

WASHINGTON (AP) ? What gender gap?

Less than two weeks out from Election Day, Republican Mitt Romney has erased President Barack Obama's 16-point advantage among women, a new Associated Press-GfK poll shows. And the president, in turn, has largely eliminated Romney's edge among men.

Those churning gender dynamics leave the presidential race still a virtual dead heat, with Romney favored by 47 percent of likely voters and Obama by 45 percent, a result within the poll's margin of sampling error, the survey shows.

After a commanding first debate performance and a generally good month, Romney has gained ground with Americans on a number of important fronts, including their confidence in how he would handle the economy and their impressions of his ability to understand their problems.

At the same time, expectations that Obama will be re-elected have slipped: Half of voters now expect the president to win a second term, down from 55 percent a month earlier.

For all the good news for Republicans, however, what matters most in the election endgame is Romney's standing in the handful of states whose electoral votes still are up for grabs. And polls in a number of those battleground states still appear to favor Obama.

As the election nears, Romney has been playing down social issues and trying to project a more moderate stance on matters such as abortion in an effort to court female voters. The AP-GfK poll, taken Friday through Tuesday, shows Romney pulling even with Obama among women at 47-47 after lagging by 16 points a month earlier.

But now his campaign is grappling with the fallout from a comment by a Romney-endorsed Senate candidate in Indiana, who said that when a woman becomes pregnant during a rape "that's something God intended."

Romney, through aides, quickly distanced himself from the remark by Republican Richard Mourdock. But Obama was happy to keep the issue current, telling a crowd in Florida on Thursday: "As we saw again this week, I don't think any politician in Washington, most of whom are male, should be making health care decisions for women," Obama said. "Women can make those decisions themselves."

A renewed focus on social issues would be an unwelcome development for Romney: Among female likely voters, 55 percent say Obama would make the right decisions on women's issues, compared with 41 percent who think Romney would.

Romney's pitch to women has been focused squarely on the economy, making the case that what women want most is to ensure their families and their country are on a solid financial footing. The poll shows that message appears to be taking root.

A month ago, women favored Obama over Romney on the economy 56 percent to 40 percent. Now, the split has shifted to 49 percent for Romney and 45 percent for Obama.

Similarly, Obama's lead among women as the candidate who better understands the people's problems has narrowed considerably, from a 58-36 Obama advantage last month to a 50-43 Obama edge now.

Monica Jensen, a 55-year-old independent from Mobile, Ala., says she voted for Obama in 2008 but will shift her vote to Romney this time, largely because of the economy.

"I'm ready for a change," she said. "I want to see the economy go in a different direction."

Ginny Lewis, a Democrat and 72-year-old retired district attorney from Princeton, Ky., says she'll vote for Romney because "I'm tired of the Republicans blaming all the debt on Democrats, so let them take over and see what they do."

Not that she's optimistic about how that will turn out, though. "I think things will get worse before they get better," she said.

Lindsey Hornbaker, a 25-year-old graduate student and nanny, hasn't been swayed by Romney's charm offensive.

Hornbaker, interviewed Wednesday in Davenport, Iowa, where she was attending an Obama rally, said Romney can tweak his tone but not what she sees as a record focused far more on top income earners and out of touch with most working families.

"I heard him go out of his way to sound so moderate during the debate," she said. "And I thought: 'Who is this? Where did this come from?' He may sound like he's focused on the middle class. But where's the record?"

Obama, meanwhile, has been working to shore up his support among men, who tend to be more Republican than women. In the 2008 election, men broke 49 percent for Obama to 48 percent for John McCain, even though Obama got 53 percent of the vote overall. The president's job approval ratings among men have tended to fall below his ratings among women throughout his first term.

A month ago, Romney's advantage among men was 13 percentage points. Now, it's down to 5 points, with most of the shift toward Obama coming among unmarried men.

Obama's election chances hinge on turning out voters like Jon Gerton, a disabled construction worker from Jonesboro, Ark. Gerton's a staunch Obama supporter ? but he didn't vote in 2008.

"It takes longer than four years to get things to the point where things are going better," Gerton said. "Four years, it's not very long."

There has been a gender gap in every presidential election since 1980. In 2008, women were 7 percentage points more likely than men to vote for Obama.

Overall, people are significantly more optimistic about the economy and unemployment in the coming year than they have been at any point in AP-GfK polling going back to March 2011, when the poll first started asking those questions. And likely voters are even more optimistic than other adults.

Nearly six in 10 likely voters think the economy will improve in the next year, up from 46 percent last month. And 42 percent think the number of unemployed Americans will drop in the next year, up from 32 percent in September.

Count Chrysta Walker, of Cedar Lake, Ind., among the voters who are sticking with Obama because they think he's got the right solutions for the fragile economy.

"He's got the middle class at heart," says the 58-year-old Walker. On the economy, she says, Obama "did as well as could be expected because he didn't get a lot of cooperation."

David Bierwirth, who owns an autograph sales business in Las Vegas, turned out at a Romney rally in Henderson, Nev., this week to show his support for the GOP nominee. To Bierwirth, his vote for Romney is all about the economy.

"I want people back to work," he says, "because then they will buy my products."

The Associated Press-GfK poll was conducted Oct. 19-23 by GfK Roper Public Affairs & Corporate Communications. It involved landline and cellphone interviews with 1,186 adults nationwide, including 839 likely voters. Results for the full sample have a margin of sampling error of plus or minus 3.5 percentage points; for likely voters it is 4.2 points.

__

Online:

http://www.ap-gfkpoll.com

___

AP News Survey Specialist Dennis Junius and Associated Press writers Stacy A. Anderson in Washington, Thomas Beaumont in Davenport, Iowa, and Ken Ritter in Henderson, Nev., contributed to this report.

___

Follow Nancy Benac on Twitter: http://www.twitter.com/nbenac

Follow Jennifer Agiesta on Twitter: http://www.twitter.com/JennAgiesta

Source: http://news.yahoo.com/ap-gfk-poll-romney-erases-obama-lead-among-101625608--election.html

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Friday, October 26, 2012

The Ceremony of Original Innocence ? 12 Foundation Circuits ...

As a result of the genetic modification of the Human DNA, almost all of our foundation circuits are in a state of disconnection, creating a distorted sense of self that has led to fear, shame, guilt and disease.

The disruption of the bio-circuitry relating to our primal resonant relationships with our mothers and fathers affects our ability to engage unconditionally in relationships. However, it is no longer necessary or ultimately effective to engage in lengthy post-mortems of childhood, casting ourselves into the trauma-vortex of past tragedies and injustices, reinforcing identities anchored in disempowering scenarios. By reconnecting the vital circuits that relate to conception, gestation, birth and childhood, healing is integrated on the DNA level.

The Ceremony of Original Innocence takes us back to our first choice, prior to our first breath, reminding us of our true identity ? creators rather than victims.

The key to this shift in perception is forgiveness, the bedrock of the shamanic journey. To embrace forgiveness is to embody the living mandala of love, upon which is based the fundamental Human ethic, acknowledging your ?response-ability? within the interconnectedness of all creation.

Although it is possible to be born with the Water Circuits connected they are almost always disrupted by guilt, regret and anger. Reconnecting these circuits clears these negative emotions, liberating relationships from destructive patterns.

The reconnection of the Thymus Circuit activates the T-cells of the immune system. This has a powerful effect on health.

With the reconnection of the Air Circuits, the pineal-hypothalamus-pituitary complex is revitalised, as the pineal is now enabled to receive the full spectrum of the geometric language of light.

Source: http://ascendingstarseed.wordpress.com/2012/10/26/the-ceremony-of-original-innocence-12-foundation-circuits-guided-meditation-from-thetemplate-org/

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The Effective Workout for Thyroid Patients 10/25 by Dr Ritamarie ...

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    On his show, Comedian Rodney Perry covers arts and entertainment, everything from comedy and politics to music and acting, with his signature comedic slant.

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  • The Bottom Line Sports Show is hosted by former NBA stars Penny Hardaway, Charles Oakley, Mateen Cleaves. Tune in to get the inside scoop on what's happening in sports today.

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  • Award-winning World Footprints is a leading voice in socially responsible travel and lifestyle. Hosts Ian & Tonya celebrate culture and heritage and bring a unique voice to the world of travel.

  • Football Reporters Online is a group of veteran football experts in the fields of coaching, scouting, talent evaluation, and writing/broadcasting/media placement. Combined, the group brings well over 100 years of expertise in sports.

  • Host John Martin interviews the nation's leading entrepreneurs and small biz experts to educate small business owners on how to be successful. Past guests have included Emeril Lagasse and Guy Kawasaki.

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  • Sylvia Global presents global conversations pertaining to women, wealth, business, faith and philanthropy. Sylvia has interviewed an eclectic mix from CEOs and musicians to fashion designers and philanthropists including Randolph Duke and Ne-Yo.

  • Seasoned entertainment reporter Robin Milling gets up close and personal with the world's most compelling celebs. From Michael Douglas to Katie Holmes to Kevin Kline to Ashley Judd to America Ferrera, she sits down in person each week with each and every A-lister.

  • Mr. Media host Bob Andelman goes one-on-one with the hottest, most influential minds from the worlds of film, TV, music, comedy, journalism and literature. That means A-listers like Kirk Douglas, Christian Slater, Kathy Ireland, Rick Fox, Chris Hansen and Jackie Collins.

  • Paula Begoun, best-selling author of Don't Go to the Cosmetics Counter Without Me, separates fact from fiction on achieving a radiant, youthful complexion at any age. She?s regularly joined by health and beauty experts who offer the latest on keeping your skin in tip-top shape.

  • Source: http://www.blogtalkradio.com/dr-ritamarie/2012/10/25/the-effective-workout-for-thyroid-patients

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